Download Aging and Cell Structure: Volume 2 by Robert O. Kelley, Kathryn G. Vogel (auth.), John E. Johnson PDF

By Robert O. Kelley, Kathryn G. Vogel (auth.), John E. Johnson Jr. (eds.)

Although millions of articles and 1000s of books on getting older were released, just a small percent of this fabric has handled anatomy, quite on the superb­ structural point. It used to be with this in brain that getting older and phone constitution used to be conceived. quantity 1 of getting older and mobilephone constitution was once released in 1981 and represented a present compilation of data, concentrating on the electron microscopic point, on morphological alterations which happen in cells and tissues as they age. the current quantity completes the two-volume set. whereas quantity 1 highlighted structural adjustments taking place within the getting older fearful process, quantity 2 facilities its efforts on reports of in vitro getting older. Chapters on different topics are incorporated in addition. those comprise age-related adjustments obvious in neuromuscular junctions, oral tissues, and the pancreas. even supposing those volumes signify a truly small a part of the printed infor­ mation on experimental gerontology, their strategy is very detailed simply because they concentrate on anatomy, maybe the main uncomplicated of all of the biomedical sciences. simply because many dif­ ferent tissue kinds are tested, we start to work out recurrent, definitive styles within the getting older mobile that may now not be totally obvious from stories taking one mobilephone kind at a time. This turns into much more obtrusive within the current quantity the place alterations noticeable in popula­ tions of cells grown in culture-isolated from hormones or frightened impulses from different physique areas-are stumbled on to be just like these adjustments present in vivo.

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Aging and Cell Structure: Volume 2

Even though millions of articles and 1000's of books on getting older were released, just a small percent of this fabric has handled anatomy, rather on the superb­ structural point. It was once with this in brain that getting older and mobilephone constitution was once conceived. quantity 1 of getting older and mobilephone constitution was once released in 1981 and represented a present compilation of knowledge, concentrating on the electron microscopic point, on morphological adjustments which take place in cells and tissues as they age.

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And Barnes, W. , 1974, Genealogies of clones of diploid fibroblasts, Exp. Cell Res. 88:95 Adelstein, R. , Scordilis, S. , and Trotter, J. , 1979, The cytoskeleton and cell movement: General considerations, Meth. Achiev. Exp. Pathol. 8:1. , 1979, Effects of glutaraldehyde and other drugs on Concanavalin Amediated red blood cell adsorption to nonsenescent, senescent and transformed human fibroblasts, Mech Ageing Devl. 11:237. , 1979, A new cell surface marker of aging in human diploid fibroblasts, J.

VOGEL Figure 9. Indirect immunofluorescence microscopy of lung fibroblast cultures at different population doubling levels and stained for fibronectin. (a) PDL 16; (b) PDL 53: Internal fluorescence of late-passage cells was yellow in color and clearly distinct from the FITC-Iabeled second antibody. Note absence of fibrillar fibronectin over large, late-passage cells. X 1000. the medium by cell cultures could be purified on a collagen-Sepharose affinity column, and this material demonstrated the usual band position by SDS-polyacrylamide gel electrophoresis (Chandrasekhar and Millis, 1978).

Correlated electron microscopy and X-ray diffraction, J. Cell Bioi. 74:605. , and Millis, A. J. , 1980, Fibronectin from aged fibroblasts is defective in promoting cellular adhesion, J. Cell. Physiol. 103:47. Choe, S-IS:, and Rose, N. , 1976, In vitro senescence of mammalian cells, Gerontology 22:89. , and Spudich, J. , 1977, Nomuscle contractile proteins: The role of actin and myosin in cell motility and shape determination, Ann. Rev. Biochem. 46:797. Clarkson, B. , 1974, The survival value of the dormant state in neoplastic and normal cell populations, in: Control of Proliferation in Animal Cells, Vol.

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